Microwave-assisted amination of a chloropurine derivative in the synthesis of acyclic nucleoside analogues

Molecules. 2005 Feb 28;10(2):508-15. doi: 10.3390/10020508.

Abstract

An efficient protocol for the amination of 6-chloropurine derivatives through nucleophilic aromatic substitution under microwave irradiation was developed and applied to the synthesis in two steps of a series of new acyclic nucleosides (acyclovir analogues) starting from commercially available compounds.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amination / radiation effects
  • Chemistry, Organic / methods
  • Chlorine Compounds / chemistry
  • Chlorine Compounds / radiation effects
  • Hydrocarbons, Acyclic / chemical synthesis
  • Microwaves*
  • Models, Biological
  • Nucleosides / chemical synthesis*
  • Purines / chemistry
  • Purines / radiation effects*

Substances

  • Chlorine Compounds
  • Hydrocarbons, Acyclic
  • Nucleosides
  • Purines
  • 6-chloropurine