Abstract
An efficient protocol for the amination of 6-chloropurine derivatives through nucleophilic aromatic substitution under microwave irradiation was developed and applied to the synthesis in two steps of a series of new acyclic nucleosides (acyclovir analogues) starting from commercially available compounds.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amination / radiation effects
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Chemistry, Organic / methods
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Chlorine Compounds / chemistry
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Chlorine Compounds / radiation effects
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Hydrocarbons, Acyclic / chemical synthesis
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Microwaves*
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Models, Biological
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Nucleosides / chemical synthesis*
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Purines / chemistry
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Purines / radiation effects*
Substances
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Chlorine Compounds
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Hydrocarbons, Acyclic
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Nucleosides
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Purines
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6-chloropurine