Abstract
Cinnamic acids have been prepared in moderate to high yields by a new direct synthesis using aromatic aldehydes and aliphatic carboxylic acids, in the presence of boron tribromide as reagent, 4-dimethylaminopyridine (4-DMAP) and pyridine (Py) as bases and N-methyl-2-pyrolidinone (NMP) as solvent, at reflux (180-190 degrees C) for 8-12 hours.
MeSH terms
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Aldehydes / chemistry*
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Boron Compounds / chemistry
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Boron Compounds / pharmacology*
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Bromides / chemistry
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Bromides / pharmacology*
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Carboxylic Acids / chemistry*
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Chemistry, Organic / methods*
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Cinnamates / chemical synthesis*
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Fatty Acids / chemistry
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Heterocyclic Compounds / chemistry
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Models, Biological
Substances
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Aldehydes
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Boron Compounds
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Bromides
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Carboxylic Acids
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Cinnamates
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Fatty Acids
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Heterocyclic Compounds
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cinnamic acid