A novel approach in cinnamic acid synthesis: direct synthesis of cinnamic acids from aromatic aldehydes and aliphatic carboxylic acids in the presence of boron tribromide

Molecules. 2005 Feb 28;10(2):481-7. doi: 10.3390/10020481.

Abstract

Cinnamic acids have been prepared in moderate to high yields by a new direct synthesis using aromatic aldehydes and aliphatic carboxylic acids, in the presence of boron tribromide as reagent, 4-dimethylaminopyridine (4-DMAP) and pyridine (Py) as bases and N-methyl-2-pyrolidinone (NMP) as solvent, at reflux (180-190 degrees C) for 8-12 hours.

Publication types

  • Evaluation Study

MeSH terms

  • Aldehydes / chemistry*
  • Boron Compounds / chemistry
  • Boron Compounds / pharmacology*
  • Bromides / chemistry
  • Bromides / pharmacology*
  • Carboxylic Acids / chemistry*
  • Chemistry, Organic / methods*
  • Cinnamates / chemical synthesis*
  • Fatty Acids / chemistry
  • Heterocyclic Compounds / chemistry
  • Models, Biological

Substances

  • Aldehydes
  • Boron Compounds
  • Bromides
  • Carboxylic Acids
  • Cinnamates
  • Fatty Acids
  • Heterocyclic Compounds
  • cinnamic acid