Nine novel C-21 steroidal glycosides substituted with orthoacetate from Dregea sinensis var. corrugata

Abstract

Nine novel steroidal glycosides substituted with the orthoacetate groups, compounds 1-5 based on the aglycon of 12-O-acetyl-20-O-benzoyl-dihydrosarcostin 8,14,18-orthoacetate and compounds 6-9 based on the aglycon of 12-O-acetyl-20-O-benzoyl-dihydrosarcostin 14,17,18-orthoacetate, were isolated from Dregea sinensis var. corrugata. Their structures were deduced on the basis of chemical and spectral evidences. Compound 1 showed moderate anti-inflammatory activity.