High-resolution MR metabolic imaging

Annu Int Conf IEEE Eng Med Biol Soc. 2007:2007:4324-6. doi: 10.1109/IEMBS.2007.4353293.

Abstract

Magnetic resonance spectroscopic imaging has been recognized for a long time as a powerful tool for biochemical imaging. However, its practical utility is still rather limited due to poor spatial resolution, low signal-to-noise ratio, and long data acquisition times. In this work, we propose a new technique that enables reconstruction of metabolite maps with high spatial resolution. This technique uses a statistical model to incorporate known anatomical boundaries for edge-preserving noise filtering. This statistical reconstruction scheme makes it possible to use very noisy data, thereby enabling the collection of high-resolution data in a reasonable amount of time. We illustrate the performance of this method with images of the N-acetyl-L-aspartate distribution from an in vivo mouse brain.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Aspartic Acid / analogs & derivatives*
  • Aspartic Acid / metabolism
  • Brain / diagnostic imaging*
  • Brain / metabolism*
  • Magnetic Resonance Imaging / methods*
  • Mice
  • Models, Biological*
  • Radiography

Substances

  • Aspartic Acid
  • N-acetylaspartate