Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination

Shunichi Takeda; Kyoko Nakamura; Yoshihito Taniguchi; Tanya T Paull

doi:10.1016/j.molcel.2007.10.016

Ctp1/CtIP and the MRN complex collaborate in the initial steps of homologous recombination

Mol Cell. 2007 Nov 9;28(3):351-2. doi: 10.1016/j.molcel.2007.10.016.

Authors

Shunichi Takeda¹, Kyoko Nakamura, Yoshihito Taniguchi, Tanya T Paull

Affiliation

¹ Department of Radiation Genetics, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo-ku, Kyoto 606-8501, Japan. stakeda@rg.med.kyoto-u.ac.jp

PMID: 17996697
DOI: 10.1016/j.molcel.2007.10.016

Abstract

In a recent issue of Molecular Cell, Limbo et al. (2007) identify a new homologous recombination factor, Ctp1 in S. pombe, a homolog of Sae2/Com1 in S. cerevisiae and CtIP in mammals, that operates cooperatively with the MRN complex.

Publication types

Review
Comment

MeSH terms

DNA Repair
DNA-Binding Proteins / genetics
DNA-Binding Proteins / metabolism
DNA-Binding Proteins / physiology*
Models, Genetic
Recombination, Genetic*
Schizosaccharomyces / genetics*
Schizosaccharomyces / metabolism
Schizosaccharomyces pombe Proteins / genetics
Schizosaccharomyces pombe Proteins / metabolism
Schizosaccharomyces pombe Proteins / physiology*

Substances

Ctp1 protein, S pombe
DNA-Binding Proteins
Schizosaccharomyces pombe Proteins