Abstract
LmrCD is an ABC-type multidrug transporter in Lactococcus lactis. LmrR encodes a putative transcriptional regulator. In a DeltalmrR strain, lmrCD is up-regulated. LmrR binds the promoter region of lmrCD and interacts with drugs that cause lmrCD up-regulation. This suggests that LmrR is a drug-dependent transcriptional regulator of lmrCD expression.
MeSH terms
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ATP-Binding Cassette Transporters / biosynthesis*
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DNA, Bacterial / metabolism
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Gene Deletion
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Gene Expression Regulation, Bacterial / genetics
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Gene Expression Regulation, Bacterial / physiology*
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Lactococcus lactis / genetics
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Lactococcus lactis / physiology*
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Multidrug Resistance-Associated Proteins / biosynthesis*
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Protein Binding
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Repressor Proteins / genetics
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Repressor Proteins / physiology*
Substances
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ATP-Binding Cassette Transporters
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DNA, Bacterial
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LmrC protein, Lactococcus lactis
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LmrD protein, Lactococcus lactis
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Multidrug Resistance-Associated Proteins
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Repressor Proteins