Nevirapine-associated rash with eosinophilia and systemic symptoms in a child with human immunodeficiency virus infection

Pediatr Infect Dis J. 2007 Nov;26(11):1053-6. doi: 10.1097/INF.0b013e318125655d.

Abstract

Drug rash with eosinophilia and systemic symptoms (DRESS Syndrome) associated with nevirapine treatment has not been previously reported in children. These findings can mimic other common illnesses, and treatment options are limited. We describe a 12-year-old girl infected with human immunodeficiency virus who developed hypersensitivity to nevirapine therapy. She was successfully treated with intravenous immune globulin.

Publication types

  • Case Reports

MeSH terms

  • Anti-HIV Agents / adverse effects*
  • Child
  • Drug Hypersensitivity / drug therapy
  • Drug Hypersensitivity / etiology*
  • Eosinophilia / chemically induced*
  • Exanthema / chemically induced*
  • Female
  • HIV Infections / drug therapy*
  • HIV Infections / virology
  • HIV-1 / drug effects
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • Nevirapine / adverse effects*
  • Reverse Transcriptase Inhibitors / adverse effects*
  • Syndrome

Substances

  • Anti-HIV Agents
  • Immunoglobulins, Intravenous
  • Reverse Transcriptase Inhibitors
  • Nevirapine