Observed and expected frequency of comorbid chronic diseases in rheumatic patients

Ann Rheum Dis. 2008 Mar;67(3):418-21. doi: 10.1136/ard.2007.078659. Epub 2007 Nov 2.

Abstract

Objective: To estimate and compare the observed and expected prevalence of the co-existence of rheumatic diseases (RD) with other chronic conditions.

Methods: The self-reported diagnosis of chronic conditions was obtained from the 2192 participants in a national health survey (Spain, 1999-2000) We compared the estimated prevalence of the co-existence of a RD with other chronic conditions, to the expected prevalence using two-sample test of proportion.

Results: The observed (O) prevalence was significantly higher than expected (E) in the following combination of self-reported diseases: RD+arterial hypertension (O/E ratio = 1.88), RD+diabetes mellitus (O/E ratio = 2.07), RD+hypercholesterolemia (O/E ratio = 1.87), RD+cardiological (O/E ratio = 1.83), and RD+digestive diseases (O/E ratio = 2.07). The prevalence of selected co-existent pairs of diseases is more frequent with increasing age and differs between women and men.

Conclusions: The excess in prevalence of some combinations of diseases may serve as a reminder to the rheumatologists that many of their patients will have co-existent disease of which they need to be aware to properly plan their management. It may also be a sign of common risk factors between diseases or of adverse events.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Distribution
  • Cardiovascular Diseases / epidemiology
  • Chronic Disease / epidemiology*
  • Comorbidity
  • Diabetes Mellitus / epidemiology
  • Digestive System Diseases / epidemiology
  • Female
  • Health Surveys
  • Humans
  • Hypercholesterolemia / epidemiology
  • Male
  • Middle Aged
  • Rheumatic Diseases / epidemiology*
  • Sex Distribution
  • Spain / epidemiology