Is energy deficiency good in moderation?

Cell. 2007 Nov 2;131(3):448-50. doi: 10.1016/j.cell.2007.10.027.

Abstract

In this issue, Pospisilik et al. (2007) demonstrate that a reduction in mitochondrial oxidative phosphorylation protects mice against obesity and diabetes. This finding suggests that the moderate deficiency in oxidative phosphorylation that is observed in peripheral tissues of insulin-resistant humans is not a causative factor in diabetes but may instead be a compensatory response.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis Inducing Factor / deficiency
  • Diabetes Mellitus / prevention & control
  • Insulin Resistance
  • Mice
  • Mitochondria / drug effects
  • Mitochondria / metabolism
  • Obesity / prevention & control
  • Organ Specificity / drug effects
  • Oxidative Phosphorylation*

Substances

  • Apoptosis Inducing Factor