From G0 to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathway

Ang Sun; Luigi Bagella; Steven Tutton; Gaetano Romano; Antonio Giordano

doi:10.1002/jcb.21609

From G0 to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathway

J Cell Biochem. 2007 Dec 15;102(6):1400-4. doi: 10.1002/jcb.21609.

Authors

Ang Sun¹, Luigi Bagella, Steven Tutton, Gaetano Romano, Antonio Giordano

Affiliation

¹ Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, BioLife Science Bldg. Suite 333, 1900 N 12th Street, Philadelphia, Pennsylvania 19122, USA.

PMID: 17979151
DOI: 10.1002/jcb.21609

Abstract

Tumor suppressor pRb/p105, pRb/p107, and pRb2/p130 genes belong to the retinoblastoma (Rb) gene family. The members of the Rb gene family and the transcription factor E2F play an essential role in regulating cell cycle and, consequently, cell proliferation. This mini-review describes the mechanisms by which Rb family members and E2F regulate cell cycle progression.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Cycle / genetics
E2F Transcription Factors / genetics
E2F Transcription Factors / metabolism*
Genes, Tumor Suppressor
Humans
Models, Biological
Multigene Family
Retinoblastoma* / genetics
Retinoblastoma* / prevention & control
Retinoblastoma-Like Protein p107 / genetics
Retinoblastoma-Like Protein p107 / metabolism*
Retinoblastoma-Like Protein p130 / genetics
Retinoblastoma-Like Protein p130 / metabolism*
S Phase*

Substances

E2F Transcription Factors
Retinoblastoma-Like Protein p107
Retinoblastoma-Like Protein p130