Abstract
A new glycosyl inositolphosphoceramide-type ganglioside, CSP2, was obtained from the polar lipid fraction of the chloroform/methanol extract of the feather star Comanthina schlegeli together with a known same type of ganglioside CJP2. The structure of this ganglioside has been determined on the basis of chemical and spectroscopic evidence to be 9-O-methyl-(N-acetyl-alpha-D-neuraminosyl)-(2-->3)-inositolphosphoceramide, which contains C(16)-sphingosine and C(22:0)-, C(24:0)-fatty acid as major component. This is the first report on the isolation and structural elucidation of a glycosyl inositolphosphoceramide-type ganglioside possessing N-acetyl-neuraminic acid (NeuAc) residue.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Carbohydrate Sequence
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Chloroform / chemistry
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Fatty Acids, Unsaturated / chemistry
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Fatty Acids, Unsaturated / isolation & purification
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Fatty Acids, Unsaturated / pharmacology
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Gangliosides / chemistry*
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Gangliosides / isolation & purification*
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Gangliosides / pharmacology
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Glycosphingolipids / chemistry*
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Glycosphingolipids / isolation & purification*
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Glycosphingolipids / pharmacology
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Methanol / chemistry
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Molecular Sequence Data
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Molecular Structure
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Spectrum Analysis
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Sphingosine / chemistry
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Sphingosine / isolation & purification
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Sphingosine / pharmacology
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Starfish / chemistry*
Substances
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9-O-methyl-(N-acetyl-alpha-D-neuraminosyl)-(2-3)-inositolphosphoceramide
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Fatty Acids, Unsaturated
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Gangliosides
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Glycosphingolipids
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inositolphosphoceramides
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Chloroform
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Sphingosine
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Methanol