Abstract
A series of ten 1-[(5-nitrothenylidene)amino]azoles has been synthesized by the reaction of 5-nitrothiophene-2-carbaldehyde with 1-aminopyrazole, 1-aminoimidazole, 1- and 4- amino-1,2,4-triazoles, 1-aminoindole, 1- and 2-aminoindazoles, 1-aminobenzimidazole and 1- and 2-aminobenzotriazoles. Physical data, spectroscopic characteristics and biological properties of all the derivatives have been examined. The antiprotozoal activity has been tested against Trypanosoma cruzi, comparative to Nifurtimox (Lampit).
MeSH terms
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Animals
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Azoles / chemical synthesis*
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Azoles / pharmacology
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Benzimidazoles / chemical synthesis
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Benzimidazoles / pharmacology
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Chagas Disease / drug therapy*
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Chagas Disease / psychology
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Imidazoles / chemical synthesis
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Imidazoles / pharmacology
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Indazoles / chemical synthesis
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Indazoles / pharmacology
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Indoles / chemical synthesis
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Indoles / pharmacology
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Mice
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Nifurtimox / pharmacology
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Nitro Compounds / chemical synthesis
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Nitro Compounds / pharmacology
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Thiophenes / chemical synthesis
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Thiophenes / pharmacology
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Triazoles / chemical synthesis
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Triazoles / pharmacology
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Trypanocidal Agents / chemical synthesis*
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Trypanocidal Agents / pharmacology
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Trypanocidal Agents / therapeutic use
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Trypanosoma cruzi / drug effects*
Substances
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Azoles
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Benzimidazoles
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Imidazoles
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Indazoles
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Indoles
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Nitro Compounds
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Thiophenes
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Triazoles
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Trypanocidal Agents
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Nifurtimox