Chiral thiols: the assignment of their absolute configuration by 1H NMR

Silvia Porto; José Manuel Seco; Aurelio Ortiz; Emilio Quiñoá; Ricardo Riguera

doi:10.1021/ol7022196

Chiral thiols: the assignment of their absolute configuration by 1H NMR

Org Lett. 2007 Nov 22;9(24):5015-8. doi: 10.1021/ol7022196. Epub 2007 Oct 31.

Authors

Silvia Porto¹, José Manuel Seco, Aurelio Ortiz, Emilio Quiñoá, Ricardo Riguera

Affiliation

¹ Departamento de Química Orgánica, Facultad de Química y Unidad de RMN de Biomoléculas Asociada al CSIC, Universidad de Santiago de Compostela, E-15782 Santiago de Compostela, Spain.

PMID: 17973398
DOI: 10.1021/ol7022196

Abstract

A general NMR spectroscopy protocol for determination of absolute configuration of thiols, that includes the introduction of new aryl-tert-butoxyacetic acids as chiral derivatizing agents (CDAs), is described.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Ligands
Magnetic Resonance Spectroscopy / methods*
Magnetic Resonance Spectroscopy / standards*
Molecular Conformation
Protons
Reference Standards
Stereoisomerism
Sulfhydryl Compounds / chemistry*

Substances

Ligands
Protons
Sulfhydryl Compounds