Efficient Ce(NO3)3 x 6H2O-catalyzed solvent-free synthesis of 3,4-dihydropyrimidin-2(1H)-ones

Mehdi Adib; Khadijeh Ghanbary; Manizheh Mostofi; Mohammad Reza Ganjali

doi:10.3390/11080649

Efficient Ce(NO3)3 x 6H2O-catalyzed solvent-free synthesis of 3,4-dihydropyrimidin-2(1H)-ones

Molecules. 2006 Aug 23;11(8):649-54. doi: 10.3390/11080649.

Authors

Mehdi Adib¹, Khadijeh Ghanbary, Manizheh Mostofi, Mohammad Reza Ganjali

Affiliation

¹ School of Chemistry, University College of Science, University of Tehran, P. O. Box 14155-6455, Tehran, Iran. madib@khayam.ut.ac.ir

Abstract

Cerium(III) nitrate hexahydrate efficiently catalyzes the three-component Biginelli reaction under solvent-free conditions of an aldehyde, a beta-keto ester or beta-diketone and urea or thiourea to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones or -thiones in excellent yields.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Cerium / chemistry*
Pyrimidinones / chemical synthesis*
Pyrimidinones / chemistry
Solvents / chemistry*
Water / chemistry*

Substances

Pyrimidinones
Solvents
Water
cerium nitrate
Cerium