Synthesis of conformationally constrained aryl- or heteroarylpiperazinyl derivatives of selected imides as 5-HT1A receptor ligands

Jerzy Kossakowski; Mariola Krawiecka; Bozena Kuran

doi:10.3390/11080615

Synthesis of conformationally constrained aryl- or heteroarylpiperazinyl derivatives of selected imides as 5-HT1A receptor ligands

Molecules. 2006 Aug 23;11(8):615-25. doi: 10.3390/11080615.

Authors

Jerzy Kossakowski¹, Mariola Krawiecka, Bozena Kuran

Affiliation

¹ Department of Medical Chemistry, Medical University, 3 Oczki St., 02-007 Warsaw, Poland. jerzykos@amwaw.edu.pl

Abstract

The preparation of a number of cyclic imide 5-HT(1A) receptor ligand derivatives has been described. Their structures were conformationally constrained by introducing rigid linkers containing unsaturated bonds or aromatic benzene rings. These compounds are expected to possess anxiolytic and antidepressant activity.

MeSH terms

Imides / chemical synthesis*
Imides / chemistry*
Ligands
Molecular Conformation
Piperazines / chemical synthesis*
Piperazines / chemistry*
Receptor, Serotonin, 5-HT1A / chemistry*

Substances

Imides
Ligands
Piperazines
Receptor, Serotonin, 5-HT1A