Annexins are calcium-dependent phospholipid-binding proteins existing both in animal and plant cells. Mammalian and especially human annexins were examined for many years, and their functions in these organisms are already well known, but it is not the case for plant annexins. On the basis of existing literature and experimental evidence, it can be proposed that plant annexins may have a role in stress response. Annexin At1 of Arabidopsis thaliana (AnnAt1) is one of eight proteins of this family in A. thaliana. In its sequence many potentially functional domains are found, owing to that this protein can play an important role in stress response of the organism. Considering literature data and our own experiments one can postulate that AnnAt1 has weak peroxidase activity and form oligomers in hydrogen peroxide-dependent manner. This can be important in response to oxidative stress. Also we found that this protein forms ion channel in pH-dependent manner. This phenomenon may have particular significance in maintaining calcium homeostasis in the cell and calcium signaling, therefore AnnAt1 may play different roles in regulating stress response of plant. This is extremely important because plants during growth and development have to cope different stress factors like drought, deficiency or excess of mineral compounds in the soil, as well as low or high temperatures.