Synthesis of chiral 3-substituted indanones via an enantioselective reductive-Heck reaction

Ana Minatti; Xiaolai Zheng; Stephen L Buchwald

doi:10.1021/jo701741y

Synthesis of chiral 3-substituted indanones via an enantioselective reductive-Heck reaction

J Org Chem. 2007 Nov 23;72(24):9253-8. doi: 10.1021/jo701741y. Epub 2007 Oct 30.

Authors

Ana Minatti¹, Xiaolai Zheng, Stephen L Buchwald

Affiliation

¹ Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

PMID: 17967034
DOI: 10.1021/jo701741y

Abstract

An efficient intramolecular palladium-catalyzed, asymmetric reductive-Heck reaction has been developed, which allowed for the synthesis of either enantiomerically enriched 3-substituted indanones or alpha-exo-methylene indanones depending on the base used.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Catalysis
Indans / chemical synthesis*
Ligands
Models, Chemical
Palladium / chemistry*

Substances

Indans
Ligands
Palladium

Abstract

Publication types

MeSH terms

Substances

Grants and funding