Therapeutic potential of Yersinia anti-inflammatory components

Adv Exp Med Biol. 2007:603:361-6. doi: 10.1007/978-0-387-72124-8_33.

Abstract

Microbial pathogens have developed various stratagems for modulating and/or circumventing the host's innate and adaptive immunity. Hence, certain virulence factors can be viewed as potential therapeutic agents for human immunopathological diseases. This is the case for virulence plasmid-encoded proteins from pathogenic Yersiniae that inhibit the host's inflammatory response by interfering with various cellular signaling pathways.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, Bacterial / genetics
  • Antigens, Bacterial / immunology
  • Colitis / immunology
  • Colitis / prevention & control
  • Humans
  • Inflammation / immunology
  • Inflammation / therapy*
  • Inflammatory Bowel Diseases / immunology
  • Inflammatory Bowel Diseases / therapy
  • Lactococcus lactis / genetics
  • Lactococcus lactis / immunology
  • Mice
  • Pore Forming Cytotoxic Proteins / genetics
  • Pore Forming Cytotoxic Proteins / immunology
  • Trinitrobenzenesulfonic Acid / toxicity
  • Virulence Factors / therapeutic use*
  • Yersinia / genetics
  • Yersinia / immunology*
  • Yersinia / pathogenicity

Substances

  • Antigens, Bacterial
  • LcrV protein, Yersinia
  • Pore Forming Cytotoxic Proteins
  • Virulence Factors
  • Trinitrobenzenesulfonic Acid