A novel indole-diterpenoid, JBIR-03 with anti-MRSA activity from Dichotomomyces cejpii var. cejpii NBRC 103559

Masahiro Ogata; Jun-ya Ueda; Midori Hoshi; Junko Hashimoto; Takuji Nakashima; Kozue Anzai; Motoki Takagi; Kazuo Shin-ya

doi:10.1038/ja.2007.83

A novel indole-diterpenoid, JBIR-03 with anti-MRSA activity from Dichotomomyces cejpii var. cejpii NBRC 103559

J Antibiot (Tokyo). 2007 Oct;60(10):645-8. doi: 10.1038/ja.2007.83.

Authors

Masahiro Ogata¹, Jun-ya Ueda, Midori Hoshi, Junko Hashimoto, Takuji Nakashima, Kozue Anzai, Motoki Takagi, Kazuo Shin-ya

Affiliation

¹ Department of Microbiology, Faculty of Pharmaceutical Sciences, Aomori University, Japan.

PMID: 17965481
DOI: 10.1038/ja.2007.83

Abstract

A new indole-diterpene, JBIR-03 (1), was isolated from the fungus Dichotomomyces cejpii var. cejpii NBRC 103559 and its structure was determined based on the spectroscopic data. 1 exhibited anti-MRSA (methicillin-resistant Staphylococcus aureus) activity and antifungal activity against apple Valsa canker-causing fungus, Valsa ceratosperma, while it exhibited no toxicity towards human cancer cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / isolation & purification
Anti-Bacterial Agents / pharmacology*
Antifungal Agents / isolation & purification
Antifungal Agents / pharmacology
Ascomycota / chemistry*
Bacteria / drug effects
Chemical Phenomena
Chemistry, Physical
Diterpenes / isolation & purification
Diterpenes / pharmacology*
Fungi / drug effects
Indoles / isolation & purification
Indoles / pharmacology*
Magnetic Resonance Spectroscopy
Methicillin Resistance*
Microbial Sensitivity Tests
Molecular Conformation
Mycelium / chemistry
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Ultraviolet
Staphylococcus aureus / drug effects*

Substances

Anti-Bacterial Agents
Antifungal Agents
Diterpenes
Indoles
JBIR-03