Stressful splicing

Mol Cell. 2007 Oct 26;28(2):180-1. doi: 10.1016/j.molcel.2007.10.004.

Abstract

A novel study in a recent issue of Molecular Cell (Shi and Manley, 2007) provides insight into a complex signaling pathway that controls the phosphorylation status of an SR-related protein that functions as a splicing repressor following heat shock-dependent dephosphorylation.

Publication types

  • Comment

MeSH terms

  • 14-3-3 Proteins / metabolism
  • Adenosine Triphosphate / metabolism
  • Amino Acid Motifs
  • Animals
  • Hot Temperature*
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Nuclear Proteins / chemistry
  • Nuclear Proteins / metabolism*
  • Phosphorylation
  • Protein Binding
  • Protein Phosphatase 1 / metabolism
  • Protein Serine-Threonine Kinases / metabolism
  • Protein Structure, Tertiary
  • Protein-Tyrosine Kinases / metabolism
  • RNA Precursors / metabolism*
  • RNA Splicing*
  • RNA, Messenger / metabolism*
  • RNA-Binding Proteins / chemistry
  • RNA-Binding Proteins / metabolism*
  • Ribonucleoproteins, Small Nuclear / metabolism
  • Serine-Arginine Splicing Factors
  • Stress, Physiological / genetics
  • Stress, Physiological / metabolism*

Substances

  • 14-3-3 Proteins
  • Intracellular Signaling Peptides and Proteins
  • Nuclear Proteins
  • RNA Precursors
  • RNA, Messenger
  • RNA-Binding Proteins
  • Ribonucleoproteins, Small Nuclear
  • protein phosphatase inhibitor-1
  • Serine-Arginine Splicing Factors
  • Adenosine Triphosphate
  • Clk dual-specificity kinases
  • Protein-Tyrosine Kinases
  • Protein Serine-Threonine Kinases
  • Protein Phosphatase 1