Evidence of dual sexual transmission of multi-resistant HIV with two years persistence of resistance to NRTI and NNRTI: a case report

M Zaccarelli; P Marconi; U Visco-Comandini; G Liuzzi; P Sette; R Acinapura; S Mosti; A Ammassari; C F Perno; A Antinori

doi:10.1007/s15010-007-6293-7

Evidence of dual sexual transmission of multi-resistant HIV with two years persistence of resistance to NRTI and NNRTI: a case report

Infection. 2008 Mar;36(2):178-80. doi: 10.1007/s15010-007-6293-7. Epub 2007 Oct 25.

Authors

M Zaccarelli¹, P Marconi, U Visco-Comandini, G Liuzzi, P Sette, R Acinapura, S Mosti, A Ammassari, C F Perno, A Antinori

Affiliation

¹ National Institute for Infectious Diseases "Lazzaro Spallanzani", Via Portuense 292, 00149, Rome, Italy. zaccarelli@inmi.it

PMID: 17962906
DOI: 10.1007/s15010-007-6293-7

Abstract

A case report of dual sexual transmission, with secondary transmission from naïve to naïve patient, of HIV harbouring K103N and L100I mutations, conferring full non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance, plus 2 nucleoside analogous reverse transcriptase inhibitor (NRTI) mutations is described. The secondary transmission of the resistant virus was confirmed by phylogenetic analysis. Data also suggest that mutations related to NRTI and NNRTI resistance may persist for a long time in naive patients, over 2 years in the present case report.

Publication types

Case Reports

MeSH terms

Adult
Anti-HIV Agents / pharmacology*
Drug Resistance, Multiple / genetics*
HIV / drug effects*
HIV / genetics
HIV Infections / transmission*
HIV Infections / virology*
HIV Reverse Transcriptase / genetics
Humans
Male
Middle Aged
Mutation
Phylogeny
Reverse Transcriptase Inhibitors / pharmacology*

Substances

Anti-HIV Agents
Reverse Transcriptase Inhibitors
HIV Reverse Transcriptase