Host-guest chemistry of tolbutamide

Molecules. 2006 Jun 23;11(6):478-85. doi: 10.3390/11060478.

Abstract

The molecular recognition features of tolbutamide with four synthetic hosts have been studied by means of NMR titrations, NOESY experiments and Monte Carlo (MC) conformational search. The interaction strength and the most probable structure reveal new insights on the recognition phenomena of this urea derivative in comparison with close related compounds.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Hypoglycemic Agents / chemistry
  • Hypoglycemic Agents / metabolism
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Molecular Conformation
  • Monte Carlo Method
  • Tolbutamide / chemistry*
  • Tolbutamide / metabolism

Substances

  • Hypoglycemic Agents
  • Tolbutamide