Abstract
A 1000-member uridinyl branched peptide library was synthesized on PS-DES support using IRORI technology. High-throughput screening of this library for anti-tuberculosis activity identified several members with a MIC(90) value of 12.5 microg/mL.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Antitubercular Agents / chemistry
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Antitubercular Agents / pharmacology
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Molecular Structure
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Mycobacterium tuberculosis / drug effects
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Peptide Library*
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Structure-Activity Relationship
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Uridine / chemistry*
Substances
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Antitubercular Agents
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Peptide Library
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Uridine