Treatment of tinnitus with acamprosate

Prog Brain Res. 2007:166:273-7. doi: 10.1016/S0079-6123(07)66025-7.

Abstract

Acamprosate, a drug used to treat alcohol dependence, was first reported as a potential treatment for tinnitus in 2005. The drug may improve tinnitus by a dual mechanism of action, acting both as a glutamate antagonist and as a GABA agonist. It is suggested that its action may be both on the ear and the nervous system.

Publication types

  • Review

MeSH terms

  • Acamprosate
  • Alcohol Deterrents / therapeutic use*
  • Excitatory Amino Acid Antagonists
  • GABA Agents / therapeutic use
  • Humans
  • Taurine / analogs & derivatives*
  • Taurine / therapeutic use
  • Tinnitus / drug therapy*

Substances

  • Alcohol Deterrents
  • Excitatory Amino Acid Antagonists
  • GABA Agents
  • Taurine
  • Acamprosate