Oral Therapy with Amlodipine and Lacidipine, 1,4-Dihydropyridine Derivatives Showing Activity against Experimental Visceral Leishmaniasis

Antimicrob Agents Chemother. 2008 Jan;52(1):374-7. doi: 10.1128/AAC.00522-07. Epub 2007 Oct 22.

Abstract

Amlodipine and lacidipine, conventional antihypertensive drugs, inhibited Leishmania donovani infection in vitro and in BALB/c mice when administered orally. These 1,4-dihydropyridine derivatives functioned through dose-dependent inhibition of oxygen consumption, triggering caspase 3-like activation-mediated programmed cell death of the parasites.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Amlodipine* / administration & dosage
  • Amlodipine* / chemistry
  • Amlodipine* / pharmacology
  • Animals
  • Antiprotozoal Agents* / administration & dosage
  • Antiprotozoal Agents* / chemistry
  • Antiprotozoal Agents* / pharmacology
  • Dihydropyridines* / administration & dosage
  • Dihydropyridines* / chemistry
  • Dihydropyridines* / pharmacology
  • Leishmania donovani / drug effects*
  • Leishmaniasis, Visceral / drug therapy*
  • Leishmaniasis, Visceral / parasitology
  • Macrophages, Peritoneal / parasitology
  • Mice
  • Mice, Inbred BALB C
  • Parasitic Sensitivity Tests
  • Treatment Outcome

Substances

  • Antiprotozoal Agents
  • Dihydropyridines
  • Amlodipine
  • 1,4-dihydropyridine