Abstract
Amlodipine and lacidipine, conventional antihypertensive drugs, inhibited Leishmania donovani infection in vitro and in BALB/c mice when administered orally. These 1,4-dihydropyridine derivatives functioned through dose-dependent inhibition of oxygen consumption, triggering caspase 3-like activation-mediated programmed cell death of the parasites.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Amlodipine* / administration & dosage
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Amlodipine* / chemistry
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Amlodipine* / pharmacology
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Animals
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Antiprotozoal Agents* / administration & dosage
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Antiprotozoal Agents* / chemistry
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Antiprotozoal Agents* / pharmacology
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Dihydropyridines* / administration & dosage
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Dihydropyridines* / chemistry
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Dihydropyridines* / pharmacology
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Leishmania donovani / drug effects*
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Leishmaniasis, Visceral / drug therapy*
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Leishmaniasis, Visceral / parasitology
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Macrophages, Peritoneal / parasitology
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Mice
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Mice, Inbred BALB C
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Parasitic Sensitivity Tests
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Treatment Outcome
Substances
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Antiprotozoal Agents
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Dihydropyridines
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Amlodipine
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1,4-dihydropyridine