No genetic bottleneck in Plasmodium falciparum wild-type Pfcrt alleles reemerging in Hainan Island, China, following high-level chloroquine resistance

Antimicrob Agents Chemother. 2008 Jan;52(1):345-7. doi: 10.1128/AAC.00711-07. Epub 2007 Oct 22.

Abstract

Chloroquine-resistant Plasmodium falciparum was highly prevalent in Hainan, China, in the 1970s. Twenty-five years after cessation of chloroquine therapy, the prevalence of P. falciparum wild-type Pfcrt alleles has risen to 36% (95% confidence interval, 22.1 to 52.4%). The diverse origins of wild-type alleles indicate that there was no genetic bottleneck caused by high chloroquine resistance.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles*
  • Animals
  • Antimalarials / pharmacology*
  • China / epidemiology
  • Chloroquine / pharmacology*
  • Drug Resistance / genetics*
  • Humans
  • Malaria, Falciparum / drug therapy
  • Malaria, Falciparum / epidemiology
  • Malaria, Falciparum / parasitology
  • Membrane Transport Proteins / genetics*
  • Plasmodium falciparum / drug effects*
  • Plasmodium falciparum / genetics
  • Prevalence
  • Protozoan Proteins / genetics*

Substances

  • Antimalarials
  • Membrane Transport Proteins
  • PfCRT protein, Plasmodium falciparum
  • Protozoan Proteins
  • Chloroquine