Abstract
Chloroquine-resistant Plasmodium falciparum was highly prevalent in Hainan, China, in the 1970s. Twenty-five years after cessation of chloroquine therapy, the prevalence of P. falciparum wild-type Pfcrt alleles has risen to 36% (95% confidence interval, 22.1 to 52.4%). The diverse origins of wild-type alleles indicate that there was no genetic bottleneck caused by high chloroquine resistance.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Alleles*
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Animals
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Antimalarials / pharmacology*
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China / epidemiology
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Chloroquine / pharmacology*
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Drug Resistance / genetics*
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Humans
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Malaria, Falciparum / drug therapy
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Malaria, Falciparum / epidemiology
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Malaria, Falciparum / parasitology
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Membrane Transport Proteins / genetics*
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Plasmodium falciparum / drug effects*
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Plasmodium falciparum / genetics
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Prevalence
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Protozoan Proteins / genetics*
Substances
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Antimalarials
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Membrane Transport Proteins
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PfCRT protein, Plasmodium falciparum
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Protozoan Proteins
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Chloroquine