Treatment of glottic carcinoma with anterior commissure involvement is under debate. Treatment spectrum includes surgery, open or endoscopic, and radiotherapy. Since similar results are reported in the literature, preferences depend on experience and skill of the person responsible for treatment. Our objective is the analysis of scientific data published in Medline, CancerLit, Cochrane Register, and EMBASE, between 1996 and 2007. Twenty-five articles matched our selection criteria. None was a controlled randomized, double-blind trial, clinical guidelines, or a meta-analysis. Eleven were historical, 7 clinical trials, 6 review articles, and 1 was a Cochrane review. There is no scientific data to support recommendations for the most effective treatment in patients with squamous cell carcinoma of the anterior commissure. The available evidence is level 5, with a D recommendation grade.