Spatial dependence of CBV-fMRI: a comparison between VASO and contrast agent based methods

Conf Proc IEEE Eng Med Biol Soc. 2006:2006:25-8. doi: 10.1109/IEMBS.2006.259553.

Abstract

In functional magnetic resonance imaging (fMRI), the cerebral blood volume (CBV) based approach with exogenous contrast agent has been found to have better spatial specificity than the widely applied blood oxygenation level-dependent (BOLD) method. Recently, an endogenous CBV-based contrast, vascular space occupancy-dependent (VASO) technique, was developed for human research. However, the spatial specificity of VASO functional maps is still unclear. In this report, VASO-weighted high-resolution functional map was obtained at 9.4 T. Its spatial dependence across cortical layers was compared to the traditional CBV-weighted fMRI map obtained using contrast agent injection. Both functional maps show good localization at the middle cortical layer.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Blood Volume / physiology
  • Brain / blood supply
  • Brain / physiology*
  • Brain Mapping / methods*
  • Cats
  • Cerebrovascular Circulation / physiology*
  • Contrast Media*
  • Female
  • Image Interpretation, Computer-Assisted / methods*
  • Magnetic Resonance Imaging / methods*
  • Reproducibility of Results
  • Sensitivity and Specificity

Substances

  • Contrast Media