Abstract
Nucleophosmin/B23 was first identified as a nucleolar protein expressed at higher levels in cancer cells compared to normal cells. Nucleophosmin/B23 has long been thus thought to have a role in tumor formation. With our efforts and others in the last 15 years, nucleophosmin/B23 has proven to have an oncogenic role. In this review, we provide evidence suggesting that nucleophosmin/B23 may be a crucial gene in regulation of cancer growth and discuss how nucleophosmin/B23 can contribute to tumorigenesis.
MeSH terms
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Animals
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E2F1 Transcription Factor / genetics
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Gene Expression Regulation, Neoplastic
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Humans
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Neoplasms / etiology*
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Nuclear Proteins / genetics
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Nuclear Proteins / physiology*
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Nucleophosmin
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Protein Processing, Post-Translational
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Proto-Oncogene Proteins c-myc / physiology
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Tumor Suppressor Protein p53 / physiology
Substances
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E2F1 Transcription Factor
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E2F1 protein, human
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MYC protein, human
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NPM1 protein, human
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Nuclear Proteins
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Proto-Oncogene Proteins c-myc
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Tumor Suppressor Protein p53
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Nucleophosmin