Electrical characteristics of various submucosal injection fluids for endoscopic mucosal resection

Dig Dis Sci. 2008 Jun;53(6):1678-82. doi: 10.1007/s10620-007-0051-7.

Abstract

Submucosal fluid injection, prerequisite to endoscopic mucosal resection, necessitates detailed evaluation for proper selection. We aimed to compare height of gastric tissues after submucosal injection, and to verify electrical implications of injectants. Porcine stomach pieces were cut out, and eight solutions were used: normal saline, 0.5% sodium hyaluronate (SH), 0.25% SH, hydroxypropyl methylcellulose, 10% glycerin, fibrinogen, 1% sodium alginate (SA), and 2.5% SA. Elevated heights were measured after submucosal injection of the eight fluids, and electrical impedance was measured for fluids plus a reference solution (0.01 N KCl) with a potentiostat electroimpedance spectrometry and an insulation-tipped knife. Resistivity was calculated thereafter. Normal saline and 10% glycerin solution showed greater height diminution. Resistivity were in the range of 80-110 Omega cm, except for 309.7 Omega cm for fibrinogen. Higher resistivity may improve performance of electrosurgery, probably by strengthening impedance and heat dissipation. Further studies are required to back up this basic experiment for clinical application.

Publication types

  • Comparative Study

MeSH terms

  • Alginates / administration & dosage
  • Alginates / pharmacology
  • Analysis of Variance
  • Animals
  • Electric Impedance
  • Fibrinogen / administration & dosage
  • Fibrinogen / pharmacology
  • Gastric Mucosa / drug effects
  • Gastric Mucosa / surgery*
  • Gastroscopy*
  • Glucuronic Acid / administration & dosage
  • Glucuronic Acid / pharmacology
  • Glycerol / administration & dosage
  • Glycerol / pharmacology
  • Hexuronic Acids / administration & dosage
  • Hexuronic Acids / pharmacology
  • Hyaluronic Acid / administration & dosage
  • Hyaluronic Acid / pharmacology
  • Injections
  • Sodium Chloride / administration & dosage
  • Sodium Chloride / pharmacology
  • Solutions / administration & dosage
  • Solutions / pharmacology*
  • Swine

Substances

  • Alginates
  • Hexuronic Acids
  • Solutions
  • Sodium Chloride
  • Glucuronic Acid
  • Fibrinogen
  • Hyaluronic Acid
  • Glycerol