Abstract
A high-yield radioiodination method for various types of molecules is described. The approach employs DMSO as precursor solvent, a reaction ratio of 2-5 precursor molecules per iodine atom, 5-10 microg oxidant, and a 10-25 microl reaction volume. The solution is vortexed at room temperature for 1-5 min and progress of the reaction is assessed by HPLC. Radioiodinated products are obtained in > or = 95% yield and meet the requirements for radiotracer imaging, biodistribution studies, and molecular and cellular biology research.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Antibodies, Monoclonal / isolation & purification
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Antibodies, Neoplasm / isolation & purification
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Chromatography, High Pressure Liquid
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Dimethyl Sulfoxide
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Immunoglobulin G / isolation & purification
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Iodine Radioisotopes / isolation & purification*
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Mice
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Radiochemistry
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Radiopharmaceuticals / chemical synthesis
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Radiopharmaceuticals / isolation & purification*
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Solvents
Substances
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Antibodies, Monoclonal
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Antibodies, Neoplasm
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B72.3 antibody
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Immunoglobulin G
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Iodine Radioisotopes
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Radiopharmaceuticals
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Solvents
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Dimethyl Sulfoxide