Elemental tomography of cancer-cell spheroids reveals incomplete uptake of both platinum(II) and platinum(IV) complexes

J Am Chem Soc. 2007 Nov 7;129(44):13400-1. doi: 10.1021/ja076281t. Epub 2007 Oct 12.

Authors

Rebecca A Alderden¹, Howard R Mellor, Szabolcs Modok, Matthew D Hall, Stephen R Sutton, Matthew G Newville, Richard Callaghan, Trevor W Hambley

Affiliation

¹ Centre for Heavy Metals Research, School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.

PMID: 17929931
DOI: 10.1021/ja076281t

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Cell Line, Tumor
Cisplatin / chemistry
Cisplatin / pharmacokinetics
Humans
Microscopy, Fluorescence
Organometallic Compounds / chemistry
Organometallic Compounds / pharmacokinetics*
Platinum / chemistry*
Sensitivity and Specificity
Spectrometry, X-Ray Emission / instrumentation
Spectrometry, X-Ray Emission / methods*
Spheroids, Cellular / chemistry
Spheroids, Cellular / drug effects
Spheroids, Cellular / metabolism*
Tissue Distribution
Tomography, X-Ray Computed / instrumentation
Tomography, X-Ray Computed / methods*

Substances

Organometallic Compounds
Platinum
Cisplatin