In vitro and in vivo antiplasmodial activity of 'saye', an herbal remedy used in Burkina Faso traditional medicine

Phytother Res. 2008 Apr;22(4):550-1. doi: 10.1002/ptr.2308.

Abstract

'Saye', a traditional medicine used in Burkina Faso, which consists of extracts of Cochlospermum planchonii (rhizome), Cassia alata (leaf) and Phyllanthus amarus (whole plant), showed a significant effect against Plasmodium falciparum and Plasmodium berghei parasites grown in vivo (IC(50) = 80.11 +/- 3.40 microg/mL; ED(50) = 112.78 +/- 32.32 mg/kg). In vitro the activity was lower.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimalarials / isolation & purification
  • Antimalarials / pharmacology*
  • Burkina Faso
  • Malaria / parasitology
  • Malaria / prevention & control*
  • Malaria, Falciparum / parasitology
  • Malaria, Falciparum / prevention & control
  • Medicine, African Traditional*
  • Mice
  • Plants, Medicinal / chemistry
  • Plasmodium berghei / drug effects*
  • Plasmodium falciparum / drug effects*

Substances

  • Antimalarials