The study concerned 206 diabetic patients, aged 35-54 years, from the urban Kragujevac area. Of this number 40.3 per cent had macrovascular disease, including vascular heart disease (34.9%), diseased leg blood vessels (12.1%) and cerebral stroke (2.4%). According to the results of discriminative analysis of potential risk factors (age, sex, body weight index, cigarette smoking, systolic and diastolic blood pressure, glycemia, triglycerides, lipoproteins, total cholesterol, HDL and LDL cholesterol, onset and duration of diabetes, family history) diabetic patients with macrovascular disease and patients with vascular heart disease predominated in female population with early onset of diabetes and high level of diastolic blood pressure.