Screening of terpenes and derivatives for antimycobacterial activity; identification of geranylgeraniol and geranylgeranyl acetate as potent inhibitors of Mycobacterium tuberculosis in vitro

Abstract

Several terpenes as well as synthetic analogues were screened for activity against Mycobacterium tuberculosis in vitro using the microplate alamar blue assay . Geranylgeraniol (MIC 1.56 microg/mL) and geranylgeranyl acetate (MIC 3.13 microg/mL) were identified as potent and selective inhibitors of M. tuberculosis.