Abstract
Increases in basal ganglia iron are well documented for neurodegenerative diseases but have not been associated with methamphetamine (METH). In this study, vervet monkeys that received two doses of METH (2 mg/kg, intramuscularly, 6 h apart) showed at 1 month, iron increases in substantia nigra pars reticulata and globus pallidus, with concurrent increases of ferritin-immunoreactivity and decreases of tyrosine hydroxylase-immunoreactivity in substantia nigra. At 1.5 years, substantia nigra tyrosine hydroxylase-immunoreactivity had recovered while iron and ferritin-immunoreactivity increases persisted. Globus pallidus and substantia nigra iron levels of the adult METH-exposed animals (age 5-9 years) were now comparable with those of drug-naive, aged animals (19-22 years), suggesting an aging-related condition that might render those regions more vulnerable to oxidative stress.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Aging / metabolism*
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Aging / pathology
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Animals
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Basal Ganglia / drug effects*
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Basal Ganglia / metabolism
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Basal Ganglia / pathology
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Basal Ganglia Diseases / chemically induced*
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Basal Ganglia Diseases / metabolism
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Basal Ganglia Diseases / physiopathology
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Central Nervous System Stimulants / toxicity
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Chlorocebus aethiops
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Disease Models, Animal
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Dopamine / metabolism
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Ferritins / drug effects
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Ferritins / metabolism
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Globus Pallidus / drug effects
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Globus Pallidus / metabolism
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Globus Pallidus / pathology
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Iron / metabolism*
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Iron Metabolism Disorders / chemically induced*
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Iron Metabolism Disorders / metabolism
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Iron Metabolism Disorders / physiopathology
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Male
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Methamphetamine / toxicity*
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Oxidative Stress / drug effects
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Oxidative Stress / physiology
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Species Specificity
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Substantia Nigra / drug effects
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Substantia Nigra / metabolism
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Substantia Nigra / pathology
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Tyrosine 3-Monooxygenase / drug effects
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Tyrosine 3-Monooxygenase / metabolism
Substances
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Central Nervous System Stimulants
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Methamphetamine
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Ferritins
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Iron
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Tyrosine 3-Monooxygenase
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Dopamine