Abstract
The water soluble polymer-copper(II) complex samples, [Cu(bpy)(2)(BPEI)]Cl(2).4H(2)O (bpy=2,2'-bipyridine, BPEI=branched polyethyleneimine), with varying degrees of copper(II) chelates content in the polymer chain, were prepared by ligand substitution method in water-ethanol medium and characterized by Infra-red, UV-visible, EPR spectral and elemental analysis methods. The interaction of these polymer-copper(II)-bipyridyl complex samples with calf thymus DNA has been explored by using electronic absorption spectroscopy, emission spectroscopy and gel electrophoresis techniques. The observed changes in the physico-chemical features of the polymer-copper(II) complex on binding to DNA suggest that the complex binds to DNA with electrostatic interaction mode. A sample of polymer-copper(II) complex was tested for its antibacterial and antifungal activity and it was found to have good antibacterial and antifungal activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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2,2'-Dipyridyl* / chemistry
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2,2'-Dipyridyl* / metabolism
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2,2'-Dipyridyl* / pharmacology
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Animals
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology
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Antifungal Agents / chemistry
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Antifungal Agents / metabolism
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Antifungal Agents / pharmacology
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Bacteria / drug effects*
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Candida albicans / drug effects*
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Copper* / chemistry
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Copper* / metabolism
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Copper* / pharmacology
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DNA / chemistry
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DNA / metabolism*
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Electrophoresis, Agar Gel
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Ligands
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Organometallic Compounds* / chemistry
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Organometallic Compounds* / metabolism
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Organometallic Compounds* / pharmacology
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Polyethyleneimine* / chemistry
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Polyethyleneimine* / metabolism
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Polyethyleneimine* / pharmacology
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Polymers / chemistry
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Spectrum Analysis
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Ligands
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Organometallic Compounds
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Polymers
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2,2'-Dipyridyl
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Copper
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Polyethyleneimine
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DNA
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calf thymus DNA