Abstract
Biodegradable poly(lactide-co-glycolide) (PLGA) particles have shown significant potential for sustained and targeted delivery of several pharmaceutical agents, including plasmid DNA (pDNA). Here, we survey current approaches to PLGA particle preparation for pDNA delivery and discuss recent progress on optimizing formulation development.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Biocompatible Materials / chemistry*
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Chemistry, Pharmaceutical / methods
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DNA / administration & dosage*
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Drug Carriers / chemistry*
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Gene Transfer Techniques
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Humans
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Plasmids / administration & dosage*
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Polyglactin 910 / chemistry*
Substances
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Biocompatible Materials
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Drug Carriers
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Polyglactin 910
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DNA