N-trans-feruloyltyramine as a melanin biosynthesis inhibitor

Biol Pharm Bull. 2007 Oct;30(10):1972-4. doi: 10.1248/bpb.30.1972.

Abstract

In this study, we examined the effect of N-trans-feruloyltyramine (FA) on melanogenesis in mouse B16 melanoma cells. Melanogenesis was inhibited by FA in a dose-dependent manner. FA exhibited a greater potency than kojic acid as a standard inhibitor of melanogenesis. Moreover, treatment of B16 melanoma cells with FA was found to cause marked decreases in the expression levels of tyrosinase. FA-induced downregulation of tyrosinase resulted in suppression of melanin biosynthesis in murine B16 melanoma cells.

MeSH terms

  • Animals
  • Annonaceae / chemistry*
  • Blotting, Western
  • Cell Line, Tumor
  • Chromatography, High Pressure Liquid
  • Coumaric Acids / isolation & purification
  • Coumaric Acids / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Melanins / antagonists & inhibitors*
  • Melanins / biosynthesis*
  • Melanoma, Experimental / drug therapy
  • Melanoma, Experimental / enzymology
  • Melanoma, Experimental / pathology
  • Mice
  • Monophenol Monooxygenase / metabolism
  • Plant Extracts / chemistry
  • Signal Transduction / drug effects
  • Spectrophotometry, Infrared
  • Tyramine / analogs & derivatives*
  • Tyramine / isolation & purification
  • Tyramine / pharmacology

Substances

  • Coumaric Acids
  • Melanins
  • Plant Extracts
  • feruloyltyramine
  • Monophenol Monooxygenase
  • Tyramine