Abstract
In this study, we examined the effect of N-trans-feruloyltyramine (FA) on melanogenesis in mouse B16 melanoma cells. Melanogenesis was inhibited by FA in a dose-dependent manner. FA exhibited a greater potency than kojic acid as a standard inhibitor of melanogenesis. Moreover, treatment of B16 melanoma cells with FA was found to cause marked decreases in the expression levels of tyrosinase. FA-induced downregulation of tyrosinase resulted in suppression of melanin biosynthesis in murine B16 melanoma cells.
MeSH terms
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Animals
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Annonaceae / chemistry*
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Blotting, Western
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Cell Line, Tumor
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Chromatography, High Pressure Liquid
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Coumaric Acids / isolation & purification
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Coumaric Acids / pharmacology*
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Melanins / antagonists & inhibitors*
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Melanins / biosynthesis*
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Melanoma, Experimental / drug therapy
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Melanoma, Experimental / enzymology
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Melanoma, Experimental / pathology
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Mice
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Monophenol Monooxygenase / metabolism
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Plant Extracts / chemistry
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Signal Transduction / drug effects
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Spectrophotometry, Infrared
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Tyramine / analogs & derivatives*
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Tyramine / isolation & purification
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Tyramine / pharmacology
Substances
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Coumaric Acids
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Melanins
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Plant Extracts
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feruloyltyramine
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Monophenol Monooxygenase
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Tyramine