Interferon gamma, IL-12, IL-12R and STAT-1 immunodeficiency diseases: disorders of the interface of innate and adaptive immunity

Steven M Holland

doi:10.1007/s12026-007-0045-8

Interferon gamma, IL-12, IL-12R and STAT-1 immunodeficiency diseases: disorders of the interface of innate and adaptive immunity

Immunol Res. 2007;38(1-3):342-6. doi: 10.1007/s12026-007-0045-8.

Author

Steven M Holland¹

Affiliation

¹ Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, CRC B3-4141 MSC 1684, Bethesda, MD 20892-1684, USA. smh@nih.gov

PMID: 17917041
DOI: 10.1007/s12026-007-0045-8

Abstract

Susceptibility to mycobacterial infection has long been associated with defects in T cell immunity, such as those conferred by HIV infection or iatrogenic immune suppression. However, despite these well-recognized predispositions to clinical disease with tuberculosis and nontuberculous mycobacteria, the genetic disorders that are relatively specific for mycobacterial infection with nontuberculous bacteria and bacille Calmette Guerin (BCG) involve the innate immune pathways, and all engage interferon gamma and IL-12 production, signaling, and availability.

MeSH terms

Humans
Immunity, Cellular / genetics
Immunity, Innate / genetics
Immunologic Deficiency Syndromes / complications
Immunologic Deficiency Syndromes / genetics*
Interferon gamma Receptor
Interferon-gamma / deficiency*
Interleukin-12 / deficiency*
Interleukin-12 / genetics
Mycobacterium Infections / immunology*
Receptors, Interferon / genetics
Receptors, Interleukin-12 / deficiency*
Receptors, Interleukin-12 / genetics
STAT1 Transcription Factor / deficiency*
STAT1 Transcription Factor / genetics

Substances

Receptors, Interferon
Receptors, Interleukin-12
STAT1 Transcription Factor
Interleukin-12
Interferon-gamma