Insertion of a magnesium(II)-octacarboranyl(hexylsulfanyl) porphyrazine into liposomes: a physico-chemical study

Biophys Chem. 2007 Dec;131(1-3):43-51. doi: 10.1016/j.bpc.2007.09.002. Epub 2007 Sep 11.

Abstract

The synthesis, characterization and liposome insertion of a novel magnesium(II) carboranyl-porphyrazine, i.e. [2,3,7,8,12,13,17,18-octakis-(1,2-dicarba-closo-dodecaboranyl)-hexylthio-5,10,15,20-porphyrazine]magnesium(II) complex, MgHECSPz, are described. MgHECSPz was designed to improve the potentiality in multiple approach anticancer therapy. Liposomal formulations with different surface charge were prepared as delivering agents. The obtained loaded vectors were characterized by DLS, SAXS, SANS and zeta potential measurements in order to define the overall properties and structural details of loaded liposomes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Drug Carriers / chemistry*
  • Fatty Acids, Monounsaturated / chemistry
  • Liposomes / chemistry*
  • Membrane Potentials
  • Metalloporphyrins / chemical synthesis
  • Metalloporphyrins / chemistry*
  • Neutron Diffraction
  • Phosphatidylethanolamines / chemistry
  • Quaternary Ammonium Compounds / chemistry
  • Scattering, Small Angle
  • X-Ray Diffraction

Substances

  • (2,3,7,8,12,13,17,18-octakis-(1,2-dicarba-closo-dodecaboranyl)-hexylthio-5,10,15,20-porphyrazine)magnesium(II)
  • 1,2-dioleoyl-glycero-3-phosphatidyl ethanolamine
  • Drug Carriers
  • Fatty Acids, Monounsaturated
  • Liposomes
  • Metalloporphyrins
  • Phosphatidylethanolamines
  • Quaternary Ammonium Compounds
  • 1,2-dioleoyloxy-3-(trimethylammonium)propane