Abstract
Oxidation of the DNA lesion 8-oxo-2'-deoxyguanosine by the two electron oxidants N,N'-ethylenebis(salicylideneanimato)oxochromium(V) (Cr(V)-salen) and bis(2-ethyl-2-hydroxybutyrato)oxochromium(V) (Cr(V)-ehba) at neutral pH forms spiroiminodihydantoin by an oxo-atom transfer mechanism. The chromium complexes are models of a DNA oxidation pathway caused by the carcinogen chromate.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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8-Hydroxy-2'-Deoxyguanosine
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Chromium / chemistry*
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Deoxyguanosine / analogs & derivatives*
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Deoxyguanosine / chemistry
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Guanosine / analogs & derivatives*
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Guanosine / chemistry
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Molecular Structure
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Oxidation-Reduction
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Spiro Compounds / chemistry*
Substances
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Spiro Compounds
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spiroiminodihydantoin
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Chromium
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Guanosine
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8-Hydroxy-2'-Deoxyguanosine
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Deoxyguanosine