Biological investigation of 131I-labeled new water soluble Ru(II) polypyridyl complex

Appl Radiat Isot. 2008 Feb;66(2):115-21. doi: 10.1016/j.apradiso.2007.07.033. Epub 2007 Sep 4.

Abstract

New [Ru(L1)(dcbpy)(NCS)2] complex was synthesized in a one-pot reaction starting from [RuCl2(p-cymene)]2, where the ligands (dcbpy=4,4'-dicarboxy-2,2'-bipyridine, L1=dipyrido[3,2-a:2',3'-c]phenazine-11-ylcarbonyl)-sodium) are introduced sequentially. The resulting complex was characterized by IR, NMR, and elemental analysis. The complex was labeled with I-131. Biodistribution study of the complex was carried out using 131I-labeled [Ru(L1)(dcbpy)(NCS)2] complex. The biodistribution study performed with albino Wistar male rats has shown that the complex has high uptake in the lung, small intestine, fat, and spleen.

MeSH terms

  • Animals
  • Iodine Radioisotopes / pharmacokinetics*
  • Male
  • Organometallic Compounds / chemical synthesis
  • Organometallic Compounds / chemistry
  • Organometallic Compounds / pharmacokinetics*
  • Photochemistry
  • Pyridines / chemical synthesis
  • Pyridines / chemistry
  • Pyridines / pharmacokinetics
  • Radiopharmaceuticals / chemical synthesis
  • Radiopharmaceuticals / chemistry
  • Radiopharmaceuticals / pharmacokinetics*
  • Rats
  • Rats, Wistar
  • Ruthenium / pharmacokinetics*
  • Solubility
  • Tissue Distribution
  • Water

Substances

  • Iodine Radioisotopes
  • Organometallic Compounds
  • Pyridines
  • Radiopharmaceuticals
  • Water
  • Ruthenium