Purpura simplex (inflammatory purpura without vasculitis): a clinicopathologic study of 174 cases

J Am Acad Dermatol. 1991 Oct;25(4):642-7. doi: 10.1016/0190-9622(91)70246-x.

Abstract

Purpura simplex manifests clinically as macular purpuric and petechial pigmented, golden, annular, or lichenoid lesions. These subtypes have been termed Schamberg's purpura, lichen aureus, Majocchi's purpura, and Gougerot-Blum purpura. Histologically, there is inflammation and hemorrhage without fibrinoid necrosis of vessels. One hundred seventy-four cases were retrospectively reviewed. In some patients, the eruption was related to medications. Treatment was usually of limited benefit. Fifty-eight of 87 patients (67%) who had follow-up data did eventually have clearing of lesions. Because of the clinical and histologic similarities among the subtypes, the inclusive term purpura simplex is favored.

MeSH terms

  • Eczema / pathology
  • Erythrocytes / pathology
  • Female
  • Follow-Up Studies
  • Hemosiderin / analysis
  • Histiocytes / pathology
  • Humans
  • Lymphocytes / pathology
  • Macrophages / chemistry
  • Macrophages / pathology
  • Male
  • Middle Aged
  • Pruritus / pathology
  • Purpura / chemically induced
  • Purpura / etiology
  • Purpura / pathology*
  • Retrospective Studies
  • Vacuoles / ultrastructure

Substances

  • Hemosiderin