Open-field sialoadenectomy is the first-choice treatment for submandibular disease. Conventional surgery is based on the transcervical approach. The present study aims to demonstrate the feasibility of a minimally invasive video-assisted sialoadenectomy and to describe a new technique to perform it. A 52-year-old man affected by chronic sialoadenitis underwent minimally invasive video-assisted sialoadenectomy under general anesthesia. The ultrasound scanning of the submandibular gland showed a 6.5-cm hypertrophic gland with dilatated intraglandular ducts and a 2-cm long intraglandular sialolith. After surgery, no static or dynamic nerve deficiencies were detected, but slight temporary deficiency of the marginalis mandibulae nerve recovered in 15 days. Cosmetic results satisfied the patient. Minimally invasive video-assisted submandibular sialoadenectomy can be a feasible and safe procedure, which could be a valid choice to conventional surgery if performed on selected cases. More experience must be collected to analyze the cost-effectiveness.