Clinical evaluation of 15% carbamide peroxide on the surface microhardness and shear bond strength of human enamel

Oper Dent. 2007 Sep-Oct;32(5):427-36. doi: 10.2341/06-142.

Abstract

Purpose: This clinical evaluation compared a neutral sodium fluoridated whitening product to a neutral non-fluoridated whitening product in terms their effects on human enamel surface microhardness (SMH) and human enamel/resin composite shear bond strength (SBS) following various treatment times.

Materials and methods: Subjects were evaluated for enamel SMH and enamel/resin SBS following 15% carbamide peroxide (CP) with and without potassium nitrate and fluoride (PF). Twenty subjects (80 first or second premolars), who were treatment-planned for premolar extraction due to orthodontic therapy, were allocated into two groups, A and B. Group A received 15% CP, while Group B received 15% CP with PF. Each patient had a control tooth, a 14-day treatment + 14-day recovery tooth, a 14-day treatment + no recovery tooth and a 4-day + no recovery tooth. Each tooth was further divided into two testing surfaces; the facial surface was used for SMH, while the lingual surface was used for SBS.

Results: The results of this study determined that there was no statistically significant difference between the effects of the two products on SMH and enamel/resin SBS. Additionally, there was no statistically significant difference between the treatment specimens compared to the controls in terms of SMH. However, there was a significant difference between the treatment groups compared to the controls in terms of enamel/resin SBS.

Conclusion: Within the limitations of this clinical study, 15% CP with and without PF does not seem to alter the SMH of human enamel. However, 15% CP with and without PF significantly reduced enamel/resin SBS immediately following tooth whitening therapy, up to 14 days post-treatment.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Carbamide Peroxide
  • Cariostatic Agents / therapeutic use
  • Child
  • Composite Resins / chemistry
  • Dental Bonding*
  • Dental Enamel / drug effects*
  • Dental Enamel / ultrastructure
  • Drug Combinations
  • Female
  • Hardness
  • Humans
  • Male
  • Nitrates / administration & dosage
  • Nitrates / therapeutic use
  • Oxidants / administration & dosage
  • Oxidants / therapeutic use*
  • Peroxides / administration & dosage
  • Peroxides / therapeutic use*
  • Potassium Compounds / administration & dosage
  • Potassium Compounds / therapeutic use
  • Prospective Studies
  • Shear Strength
  • Sodium Fluoride / administration & dosage
  • Sodium Fluoride / therapeutic use
  • Stress, Mechanical
  • Time Factors
  • Tooth Bleaching*
  • Urea / administration & dosage
  • Urea / analogs & derivatives*
  • Urea / therapeutic use

Substances

  • Cariostatic Agents
  • Composite Resins
  • Drug Combinations
  • Nitrates
  • Oxidants
  • Peroxides
  • Potassium Compounds
  • Carbamide Peroxide
  • Urea
  • Sodium Fluoride
  • potassium nitrate