Abstract
Primary adrenal leiomyosarcomas (LMS) are extremely rare mesenchymal tumors. To the best of our knowledge only 12 cases (9 cases of conventional and 2 cases of pleomorphic LMS) have been reported in the literature until the present date. Herein we report a case of pleomorphic LMS in a 47-year-old woman who presented with severe abdominal pain. Computed tomography showed a large heterogeneous left adrenal mass abutting the renal vessels. The adrenal mass was resected and histopathologic examination revealed a highly pleomorphic malignant spindle cell neoplasm diffusely infiltrating the adrenal parenchyma with an immunoprofile consistent with that of a leiomyosarcoma. Clinical management and subsequent follow-up of this patient is presented.
MeSH terms
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Abdominal Pain / etiology
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Adrenal Gland Neoplasms / complications
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Adrenal Gland Neoplasms / pathology*
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Adrenal Gland Neoplasms / therapy
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Adrenalectomy
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Combined Modality Therapy
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Deoxycytidine / administration & dosage
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Deoxycytidine / analogs & derivatives
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Docetaxel
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Female
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Gemcitabine
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Humans
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Leiomyoma / pathology
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Leiomyosarcoma / complications
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Leiomyosarcoma / pathology*
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Leiomyosarcoma / secondary
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Leiomyosarcoma / therapy
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Liver Neoplasms / drug therapy
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Liver Neoplasms / secondary
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Lung Neoplasms / drug therapy
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Lung Neoplasms / secondary
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Middle Aged
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Neoplasms, Second Primary / pathology
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Nephrectomy
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Radiotherapy, Adjuvant
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Taxoids / administration & dosage
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Thrombophlebitis / etiology
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Uterine Neoplasms / pathology
Substances
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Taxoids
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Deoxycytidine
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Docetaxel
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Gemcitabine