Vernonia polyanthes as a new source of antiulcer drugs

Victor Barbastefano; Maira Cola; Anderson Luiz-Ferreira; Elisângela Farias-Silva; Clélia A Hiruma-Lima; Daniel Rinaldo; Wagner Vilegas; Alba R M Souza-Brito

doi:10.1016/j.fitote.2007.07.003

Vernonia polyanthes as a new source of antiulcer drugs

Fitoterapia. 2007 Dec;78(7-8):545-51. doi: 10.1016/j.fitote.2007.07.003. Epub 2007 Aug 9.

Authors

Victor Barbastefano¹, Maira Cola, Anderson Luiz-Ferreira, Elisângela Farias-Silva, Clélia A Hiruma-Lima, Daniel Rinaldo, Wagner Vilegas, Alba R M Souza-Brito

Affiliation

¹ Departamento de Fisiologia e Biofísica, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Cidade Universitária Zeferino Vaz, s/n, CP 6109, CEP13083-970, Campinas, SP, Brazil. vicbio@yahoo.com

PMID: 17904766
DOI: 10.1016/j.fitote.2007.07.003

Abstract

Methanolic (VPME) and chloroformic (VPCL) extracts, obtained from the aerial parts of Vernonia polyanthes, were investigated for its antiulcerogenic properties. Administration of VPME (250 mg/kg) and VPCL (50 mg/kg) significantly inhibited the gastric mucosa damage (64% and 90%, respectively) caused by absolute ethanol (p.o.). Otherwise, in NSAID-induced gastric damage, their gastroprotective effects have decreased. Since the VPCL extract resulted to be more effective than the VPME we focused our efforts over VPCL action mechanism of action.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anti-Inflammatory Agents, Non-Steroidal
Anti-Ulcer Agents / administration & dosage
Anti-Ulcer Agents / pharmacology*
Anti-Ulcer Agents / therapeutic use
Dose-Response Relationship, Drug
Ethanol
Male
Phytotherapy*
Plant Components, Aerial
Plant Extracts / administration & dosage
Plant Extracts / pharmacology*
Plant Extracts / therapeutic use
Rats
Rats, Wistar
Stomach Ulcer / chemically induced
Stomach Ulcer / prevention & control*
Vernonia*

Substances

Anti-Inflammatory Agents, Non-Steroidal
Anti-Ulcer Agents
Plant Extracts
Ethanol