Glucocorticoid and sex hormone receptors: clinical implications and therapeutic relevance

Christina Stefanaki; George P Chrousos; Andreas Katsambas

doi:10.1016/j.det.2007.06.011

Glucocorticoid and sex hormone receptors: clinical implications and therapeutic relevance

Dermatol Clin. 2007 Oct;25(4):503-13, viii. doi: 10.1016/j.det.2007.06.011.

Authors

Christina Stefanaki¹, George P Chrousos, Andreas Katsambas

Affiliation

¹ Department of Dermatology, Andreas Sygros Hospital for Skin Diseases, University of Athens, 5 Ionos Dragoumi Street, Kaisariani, Athens 16121, Greece.

PMID: 17903609
DOI: 10.1016/j.det.2007.06.011

Abstract

In general, steroid hormones exert their effects through intracellular receptors, the glucocorticoid (GR), mineralocorticoid (MR), androgen (AR), estrogen (ER), and progesterone (PR) receptors. In this brief review, we will focus on glucocorticoid and sex hormone actions in the skin through their distinct receptors and discuss their clinical relevance.

Publication types

Review

MeSH terms

Animals
Dermatologic Agents / pharmacology
Dermatologic Agents / therapeutic use
Female
Gene Expression Regulation / physiology
Humans
Male
Receptors, Androgen / drug effects
Receptors, Androgen / physiology*
Receptors, Estrogen / drug effects
Receptors, Estrogen / physiology*
Receptors, Glucocorticoid / drug effects
Receptors, Glucocorticoid / physiology*
Signal Transduction / physiology
Skin Diseases / drug therapy
Skin Diseases / physiopathology*
Skin Physiological Phenomena*

Substances

Dermatologic Agents
Receptors, Androgen
Receptors, Estrogen
Receptors, Glucocorticoid