Detection and visualization of surface-pockets to enable phenotyping studies

IEEE Trans Med Imaging. 2007 Sep;26(9):1283-90. doi: 10.1109/TMI.2007.903570.

Abstract

In this paper, we propose a technique for detecting pockets on a surface-of-interest. A sequence of propagating fronts converging to the target surface is used as the basis for inspection. We compute a correspondence function between the initial and the target surface. This leads to a natural definition of the local feature size measured as the evolution distance between mapped points. Surface pockets are then extracted as salient clusters embedded in the feature space. The level-set initialization also determines the scale-space of the extracted pockets. Results are presented on a case-study in which the focus is to chronicle the phenotyping differences in genetically modified mouse placenta. Our results are validated based on manually verified ground-truth.

Publication types

  • Evaluation Study

MeSH terms

  • Algorithms
  • Animals
  • Artificial Intelligence
  • Female
  • Image Enhancement / methods
  • Image Interpretation, Computer-Assisted / methods*
  • Imaging, Three-Dimensional / methods
  • Mice
  • Pattern Recognition, Automated / methods*
  • Phenotype
  • Placenta / metabolism*
  • Placenta / pathology*
  • Placenta Diseases / genetics*
  • Placenta Diseases / pathology*
  • Pregnancy
  • Pregnancy, Animal
  • Reproducibility of Results
  • Retinoblastoma Protein / genetics*
  • Sensitivity and Specificity
  • Surface Properties
  • User-Computer Interface

Substances

  • Retinoblastoma Protein